Fat Loss peptides

18 peptides tagged fat loss. Each page carries the dosing reference, mechanism, evidence grade and references.

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  • 5-Amino-1MQ

    Small-molecule NNMT inhibitor (5-amino-1-methylquinolinium), not a peptide; in diet-induced obese mice it lowered body weight and fat mass and raised adipocyte NAD+ without changing food intake.

    Evidence: Preclinical

  • Adipotide (FTPP)

    Proapoptotic peptidomimetic that binds prohibitin on white-fat blood vessels; 4 weeks of daily dosing cut body weight 7 to 15% in obese rhesus monkeys, with reversible kidney tubule effects.

    Evidence: Preclinical

  • AOD9604

    Modified hGH fragment (Tyr plus hGH 177-191) that reduced weight gain and raised fat oxidation in obese rodents; six human trials found no IGF-1 or glucose effects, with efficacy results unpublished.

    Evidence: Preclinical

  • Cagrilintide

    Long-acting lipidated amylin analog that activates amylin and calcitonin receptors; once-weekly 0.3 to 4.5 mg cut body weight 6.0 to 10.8% at 26 weeks in a phase 2 trial (n=706).

    Evidence: Clinical

  • Fragment 176-191 + Mod GRF + Ipamorelin

    Vial blend of a GH fragment sold as 176-191, Mod GRF 1-29 and ipamorelin (12 mg: 6/3/3 mg); fat-loss claims rest on rodent data, and no study has tested the mix.

    Evidence: Preclinical

  • GH Fragment 176-191

    Synthetic C-terminal fragment of human growth hormone (residues 176-191). Related fragments cut fat gain in obese rodents; the one study of 176-191 itself found a brief rise in blood glucose in rats.

    Evidence: Preclinical

  • GW501516

    Small-molecule PPAR-delta agonist (Cardarine), not a peptide. Raised HDL and lowered LDL and triglycerides in 2 to 12 week human trials; development stopped after rodent studies found tumours at all doses.

    Evidence: Clinical

  • Liraglutide

    Once-daily acylated GLP-1 analog; FDA-approved for type 2 diabetes (2010) and obesity (2014), with generics since 2024. In SCALE, 3 mg lost 8.4 kg over 56 weeks versus 2.8 kg on placebo.

    Evidence: Clinical

  • Mazdutide

    Oxyntomodulin-based GLP-1 and glucagon receptor dual agonist peptide; approved in China by the NMPA in 2025 for weight management and type 2 diabetes; 14.0% weight loss at 6 mg over 48 weeks in phase 3.

    Evidence: Clinical

  • Orforglipron

    Small-molecule, non-peptide oral GLP-1 receptor agonist; approved by the FDA in April 2026 as Foundayo for weight management after 72-week phase 3 trials (11.2% loss at the top dose).

    Evidence: Clinical

  • Retatrutide

    Investigational once-weekly agonist of GIP, GLP-1 and glucagon receptors; in the 80-week TRIUMPH-1 phase 3 trial (n=2339), 12 mg gave 25.0% weight loss versus 3.9% with placebo.

    Evidence: Clinical

  • Semaglutide

    Acylated GLP-1 receptor agonist; FDA-approved for type 2 diabetes (2017) and obesity (2021). In STEP 1, 2.4 mg weekly gave 14.9% weight loss at 68 weeks versus 2.4% with placebo.

    Evidence: Clinical

  • SLU-PP-332

    Small-molecule ERR-alpha/beta/gamma pan-agonist studied as an exercise mimetic; shown in mice to switch on exercise-like gene programs, raising fat oxidation and endurance.

    Evidence: Preclinical

  • Survodutide

    Glucagon and GLP-1 receptor dual agonist peptide (BI 456906); in phase 3 SYNCHRONIZE-1, 3.6 and 6.0 mg weekly cut body weight 12.2 to 13.0% vs 5.4% with placebo at 76 weeks.

    Evidence: Clinical

  • Tesamorelin

    Synthetic GHRH(1-44) analog, FDA-approved 2010 (Egrifta) for excess abdominal fat in HIV lipodystrophy; cut visceral fat about 15% vs placebo over 26 weeks in two phase 3 RCTs (n=806).

    Evidence: Clinical

  • Tesamorelin + Ipamorelin Blend

    Vial blend of tesamorelin and ipamorelin (vendors sell 6/2 mg and 10/3 mg); tesamorelin cut visceral fat in HIV phase 3 trials, and no study has tested the pair.

    Evidence: Preclinical

  • Tesofensine

    Small-molecule triple monoamine reuptake inhibitor, not a peptide. In a 24-week phase 2 trial (n=203), 0.5 mg daily gave 9.2% weight loss versus 2.0% with placebo plus diet.

    Evidence: Clinical

  • Tirzepatide

    Dual GIP and GLP-1 receptor agonist; FDA-approved for type 2 diabetes (2022) and obesity (2023). In SURMOUNT-1, 15 mg weekly gave 20.9% weight loss at 72 weeks versus 3.1% with placebo.

    Evidence: Clinical

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