Sleep peptides

4 peptides tagged sleep. Each page carries the dosing reference, mechanism, evidence grade and references.

PeptideLab is an educational platform for learning about peptides. The information here is for educational and research purposes only. It is not medical advice, diagnosis, or treatment, and PeptideLab does not claim to diagnose, treat, cure, or prevent any disease or health condition. Many peptides discussed have not been approved for human use by the FDA or other regulatory bodies. Consult a qualified healthcare professional before making any health-related decision.

  • DSIP

    Endogenous nonapeptide first isolated from rabbit brain; older, small human studies looked at sleep onset, stress-axis normalization and chronic pain.

    Evidence: Clinical

  • Epithalon

    Synthetic tetrapeptide Ala-Glu-Asp-Gly (PubChem CID 219042); human cell cultures show telomerase induction, and in mice it raised maximum but not mean lifespan.

    Evidence: Preclinical

  • MK-677

    Ibutamoren, an orally active non-peptide ghrelin receptor agonist that raises GH and IGF-1 in human trials; studied for lean mass, bone density, and sleep quality.

    Evidence: Clinical

  • Orexin A

    Hypothalamic neuropeptide (hypocretin-1) acting at OX1R and OX2R to promote wakefulness and arousal; intranasal delivery studied in sleep-deprived primates and narcolepsy models.

    Evidence: Clinical

Other categories