Fertility peptides

5 peptides tagged fertility. Each page carries the dosing reference, mechanism, evidence grade and references.

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  • Gonadorelin (GnRH)

    Synthetic GnRH decapeptide; pulsatile doses raise LH and FSH, continuous exposure suppresses them. US human products Factrel (1982) and Lutrepulse (1989) are discontinued.

    Evidence: Clinical

  • HCG

    Urine-derived placental glycoprotein acting on the LH receptor; labeled IM as Pregnyl and Novarel for cryptorchidism, male hypogonadotropic hypogonadism and ovulation induction. TRT use is off-label.

    Evidence: Clinical

  • HMG

    Urine-derived menotropins with FSH and LH activity; Menopur (2004) is the only marketed US product, labeled for follicle development in IVF. Pergonal, Humegon and Repronex are discontinued.

    Evidence: Clinical

  • Kisspeptin-10

    Ten-residue C-terminal kisspeptin fragment that activates KISS1R (GPR54); IV doses raised LH and LH pulse frequency in small human studies. Not approved anywhere; on FDA's 503A safety list.

    Evidence: Preclinical

  • Triptorelin

    Synthetic decapeptide GnRH agonist; one dose triggers an LH and FSH surge, continued exposure suppresses them. FDA-labeled depots treat prostate cancer (Trelstar) and precocious puberty (Triptodur).

    Evidence: Clinical

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